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青钱柳Cyclocarya paliurus(Batal.)Iljinsk.是胡桃科青钱柳属植物，也是我国特有的珍稀植物，其根、枝、叶均具有药用价值，并具有杀虫止痒、消炎止痛祛风的功效。青钱柳中的化学成分主要包括多糖类、黄酮类、三萜类及酚酸类等，具有降血糖、降血压、降血脂、抗氧化、抗炎和保肝等多种药理作用。通过总结青钱柳的化学成分和药理作用研究进展，结合中药质量标志物(quality marker, Q-Marker)理论，从化学成分特有性、传统药效、化学成分可测性、入血成分和网络药理学评价等多个角度对青钱柳的Q-Marker进行预测分析。预测结果显示青钱柳多糖、黄酮类和三萜类可作为青钱柳Q-Marker的潜在物质种类。初步推测达玛烷型三萜类化合物(如甜茶树苷A、青钱柳苷I和青钱柳皂苷Z5～Z8等)、异槲皮苷、槲皮素-3-O-β-D-葡萄糖醛酸苷、山柰酚-3-O-β-D-葡萄糖醛酸苷、木犀草素、芹菜素、阿江榄仁酸、青钱柳酸B、对香豆酸、4,5-O-二咖啡酰奎宁酸、绿原酸和迷迭香酸等成分可作为青钱柳Q-Marker。为建立系统的青钱柳药材质量评价体系提供参考，同时对确保青钱柳药材的质量具有指导作用，进一步推动青钱柳的合理开发应用。
Abstract：Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja]is a plant of the genus Cyclocarya of the Juglandaceae family, and it is a rare and precious species found only in China.Its roots, branches and leaves all have medicinal value and are known to have insect-killing, itch-stopping, anti-inflammatory and pain-relieving properties.Its chemical composition mainly includes polysaccharides, flavonoids, triterpenoids, phenolic acids and so on.It has a variety of pharmacological effects such as hypoglycemia, hypotension, hypolipidemia, antioxidant, anti-inflammatory and hepatoprotective.By summarizing the research progress of chemical composition and pharmacological effects of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja]and combining with the theory of quality marker(Q-Marker),the Q-Marker of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja]was predicted and analyzed from various perspectives, such as chemical composition uniqueness, traditional medicinal efficacy, chemical composition measurability, blood-entry components and network pharmacological evaluation.The results revealed that polysaccharides, flavonoids and triterpenoids can be used as potential species of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja]quality markers.It was initially hypothesized that dammarane-type triterpenoids(such as cyclocarioside A,cyclocarioside I and cyclocarioside Z5-Z8),isoquercitrin, quercetin-3-O-β-D-glucuronide, kaempferol-3-O-β-D-glucuronide, luteolin, apigenin, arjunolic acid, cyclocaric acid B,p-coumaric acid, 4,5-O-dicaffeoylquinic acid, chlorogenic acid and rosmarinic acid can be used as the Q-Marker of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja].The results provided a reference for the establishment of a systematic quality evaluation system of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja]and a guiding role in ensuring the quality of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja],and further promoted the rational development and application of Qingqianliu[Cyclocarya paliurus(Batal.)Ijinskaja].
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基本信息:
DOI：10.13193/j.issn.1673-7717.2025.05.028
中图分类号:R285;R284.1
引用信息:
[1]聂春梅,肖箐,易子漾等.青钱柳化学成分和药理作用研究进展及其质量标志物预测分析[J].中华中医药学刊,2025,43(05):144-158+287.DOI:10.13193/j.issn.1673-7717.2025.05.028.
基金信息:
国家自然科学基金面上项目(82474502); 湖南省自然科学基金项目(2022JJ50047); 湖南省科学技术厅重点项目(2022ZYC024,2022GK4015); 湖南中医药大研究生创新项目(2022CX188,2023CX56)