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非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)已成为全球最常见的慢性肝病，发病率逐年上升，除了对肝脏本身造成严重损伤外，还是全身代谢性疾病及心脑血管疾病的独立危险因素。自噬是NAFLD发病的一个重要自我保护机制。根据中医“取类比象”思想，中医认为“阳虚阴盛”导致NAFLD的发病病机与自噬导致NAFLD的发病机制相类似。因此，从生理、病理、诊治等方面分析NAFLD中阴阳与自噬之间联系。深入微观层面运用自噬与中医阴阳联系诱导恢复机体“阴阳平衡”指导NAFLD治疗，即恢复自噬功能(阳)、减少脂滴沉积(痰湿、瘀血等阴邪),为本病的理论研究及临床防治提供参考。
Abstract：Non alcoholic fatty liver disease(NAFLD) has become the most common chronic liver disease in the world. The incidence rate is increasing year by year. In addition to causing serious damage to the liver itself, it is also an independent risk factor for systemic metabolic diseases and cardiovascular and cerebrovascular diseases. Autophagy is an important self-protection mechanism in the pathogenesis of NAFLD. According to the concept of “analogical analogy” in traditional Chinese medicine, it is believed that the pathogenesis of NAFLD caused by “Yang deficiency and Yin excess” is similar to that caused by autophagy. Therefore, this article analyzed the relationship between Yin-Yang and autophagy in NAFLD from the aspects of physiology, pathology, diagnosis and treatment. Exploring the micro level application of autophagy and the connection between Yin and Yang in traditional Chinese medicine to induce the restoration of “Yin-Yang balance” of the body and guide the treatment of NAFLD,that is, restoring autophagy function(Yang) and reducing lipid droplet deposition(phlegm dampness, blood stasis and other Yin pathogens),providing reference for theoretical research, clinical prevention and treatment of this disease.
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基本信息:
DOI：10.13193/j.issn.1673-7717.2025.09.002
中图分类号:R259
引用信息:
[1]周晓玲,阮博文,冯丽娟等.基于自噬和中医阴阳微观联系探讨非酒精性脂肪肝病的防治[J].中华中医药学刊,2025,43(09):7-10.DOI:10.13193/j.issn.1673-7717.2025.09.002.
基金信息:
国家自然科学基金项目(81560756); 广西岐黄学者培养项目(2022-03-07); 柳州市中央引导地方科技发展资金项目(2023YRZ0102)