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目的 探讨调冲汤加减治疗肾虚肝郁型不孕的效果及对患者激素水平的影响。方法 选取2023年3月—2024年3月门诊就诊的98例肾虚肝郁型不孕患者，简单随机分为两组，每组49例。对照组予以常规西药来曲唑，观察组予以调冲汤加减联合常规西药。比较两组临床疗效、治疗前后中医证候积分、激素水平[卵泡刺激素(follicle stimulating hormone,FSH)、促黄体生成素(luteinizing hormone,LH)、睾酮(testosterone,T)]、最大卵泡直径、子宫内膜厚度、周期排卵率、妊娠率。结果 观察组治疗总有效率95.92%(47/49)，高于对照组的81.63%(40/49)(P<0.05);观察组疗程结束后中医证候积分低于对照组(P<0.05);观察组疗程结束后、治疗后6个月血清FSH、LH、T水平低于对照组(P<0.05);观察组疗程结束后、治疗后6个月最大卵泡直径、子宫内膜厚度高于对照组(P<0.05);观察组周期排卵率、妊娠率均高于对照组(P<0.05)。结论 调冲汤加减联合常规西药能通过调节激素分泌，改善子宫生理机能，提高治疗效果，缓解肾虚肝郁型不孕患者临床体征，提升妊娠率。
Abstract：Objective To investigate the effect of Modified Tiaochong Decoction(调冲汤加减) in the treatment of infertility of kidney deficiency and liver depression and its effect on hormone levels of the patients. Methods From January 2023 to January2024,98 cases of infertility patients with kidney deficiency and liver stagnation were selected and simply randomized into groups,with 49 cases in each group. The control group was given conventional western medicine clomiphene,and the observation group was given Tiaochong Decoction combined with conventional western medicine. The clinical efficacy,traditional Chinese medicine(TCM) syndrome scores,hormone levels[follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T) ],maximum follicle diameter,endometrial thickness,ovulation rate and pregnancy rate of two groups were compared. Results The total effective rate of treatment in the observation group was 95. 92%(47/49),higher than that in the control group[81. 63%(40/49) ](P < 0. 05). After treatment,the symptoms scores of TCM in the observation group were lower(P < 0. 05). At the end of the treatment and 6 months after treatment,the serum levels of FSH,LH and T in the observation group were lower(P < 0. 05).The maximum follicular diameter and endometrial thickness of the observation group at the end of treatment and 6 months after treatment were higher than those of the control group(P < 0. 05). The ovulation rate and pregnancy rate in the observation group were higher(P < 0. 05). Conclusion The combination of Modified Tiaochong Decoction combined with conventional western medicine can improve the uterine physiological function and the treatment effect by regulating hormone secretion,relieve the clinical signs of the infertility patients with kidney deficiency and liver depression,and increase the pregnancy rate.
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基本信息:
DOI：10.13193/j.issn.1673-7717.2026.05.011
中图分类号:R271.14
引用信息:
[1]颜晓钏,缪晨韵,林倍倍,等.调冲汤加减治疗肾虚肝郁型不孕效果及对激素水平的影响研究[J].中华中医药学刊,2026,44(05):57-60.DOI:10.13193/j.issn.1673-7717.2026.05.011.
基金信息:
国家自然科学基金青年科学基金项目(82305296)
2025-07-21
2025-07-21
2025-07-21