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目的基于中医传承辅助平台及网络药理学方法,探讨陈可冀院士治疗冠状动脉粥样硬化性心脏病的组方规律及核心药物作用机制,为冠心病的防治提供客观依据。方法收集陈可冀院士治疗冠心病门诊和病房处方,通过中医传承辅助平台挖掘相关用药规律,对核心处方活性成分及冠心病主要靶点进行网络药理学机制分析。结果筛选治疗冠心病方剂147首,分析得出陈可冀院士治疗冠心病的常用药物有丹参、川芎等33种,核心组合模式17组,发现槲皮素、木犀草素、山柰酚、丹参酮IIA等成分是核心处方药物治疗冠心病的主要成分,涉及环氧合酶2(PTGS2)、丝氨酸蛋白激酶1(MAPK1)、丝氨酸蛋白激酶3(MAPK3)、苏丝氨酸特异性蛋白激酶1(AKT1)等核心靶点。结论通过中医传承辅助平台,进行挖掘、关联规则分析等方法较好体现了陈可冀院士治疗冠心病的用药规律,即活血化瘀、宣痹通阳、芳香温通与补气血、补肾结合辨证施治,并初步揭示了陈可冀院士治疗冠心病用药的多靶点作用机制,为临床应用提供基础。
Abstract：Objective Based on the Traditional Chinese Medicine Inheritance Support Platform and network pharmacology methods, to explore the prescription rules of academician CHEN Keji in the treatment of coronary heart disease and the core drug action mechanism, so as to provide an objective basis for the prevention and treatment of coronary heart disease. Methods The outpatient prescriptions of academician CHEN Keji in the treatment of coronary heart disease and excavating relevant drug usage rules were collected through the TCMISP. The network pharmacological analysis of core prescriptions was conducted, and the active ingredients and main targets of coronary heart disease were obtained for mechanism analysis. Results A total of 147 prescriptions for the treatment of coronary heart disease were screened. The analysis showed that Academician CHEN Keji's commonly-used drugs for the treatment of coronary heart disease included 33 kinds of drugs such as Chuanxiong(Chuanxiong Rhizoma) and Danshen(Salviae Miltiorrhizae Radix Et Rhizoma). The core combination mode was 17 groups. Quercetin, Luteolin, Kaempferol, Tanshinone IIA and other ingredients were found as the main components of core prescription drugs for the treatment of coronary heart disease, involving core targets such as PTGS2, MAPK1, MAPK3, and AKT1. Conclusion Such as text mining and association rule analysis reflect the medication rules of academician CHEN Keji in the treatment of coronary heart disease, which means promoting blood circulation, warming Yang, relieving pain, promoting Qi and protecting kidney. It also preliminarily revealed the multi-target action mechanism of treating coronary heart disease, providing a basis for clinical application.
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基本信息:
DOI：10.13193/j.issn.1673-7717.2022.02.018
中图分类号:R249;R259
引用信息:
[1]于宗良,王泽平,张晓囡,等.基于数据挖掘的陈可冀院士治疗冠状动脉粥样硬化性心脏病用药规律及机制研究[J].中华中医药学刊,2022,40(02):81-85+267.DOI:10.13193/j.issn.1673-7717.2022.02.018.
基金信息:
国家自然科学基金面上项目(81973689,82074254); 北京自然科学基金(7202176)
2021-08-20
2021-08-20
2021-08-20